Osteoarthritis and Chondrocytes

Hey guys,

I found just a quick blurb on a possible explanation of how chondrocytes may contribute to the onset of osteoarthritis. It appears that the chondrocytes will eventually begin to proflirate and spread. Their gene expressions possily upregualte the MMPs and other things that possibly degrade the cartilage within oue bodies. It explains how this upregulates bone-specific collagen type I and X which can cuase calcification and hardeneing of the cartliage. It also states how certain expressed genes are in part of the growth plate which might be why there is such an onset of osteoarthritis due to chondrocytes.

I thought it was in an interesting short blurb basically explaining in short and brief what a couple of the articles we read suggested.

http://www.medscape.com/viewarticle/579393_9

This link also guides to morth in depth discussion and the other parts to the article and are kind of fascinating!

I hope you all enjoyed arthitis!

Michele