http://www.emaxhealth.com/1275/intranasal-stem-cells-improve-motor-function-parkinsons
http://online.liebertpub.com/doi/abs/10.1089/rej.2010.1130?journalCode=rej
As promised, in the articles listed above, is more information regarding the promising stem cell treatment of Parkinson's disease. The first one being a summary of the research, or a lay article and the second being the actual published research article. I didn't notice before bringing up the article in class, but one of the author's, Lusine Danielyan, MD, of University Hospital of Tubingen in Germany included in the article we focused on in class titled "Snorting Stem Cells" also reported on the results of their latest work using stem cells to treat Parkinson’s disease published on Feb. 3rd in Rejuvenation Research (in the journal link above).
The numbers I reported in class were a bit skewed because as stated in the lay article, the mesenchymal stem cells sprayed into the rat noses migrated to the brain and survived for at least 6 months. Dopamine levels increased in previously damaged areas and motor functions improved up to 68% of normal in the stem cell treated rats. I got the number '36' from the part of the lay article that reports, "In 2009, scientists from the University of California, Los Angeles, reported on the world’s first clinical trial using autologous (derived from the patient) neural stem cells for treatment of Parkinson’s." Although only one patient was treated, the authors reported that the individual’s motor scales improved by more than 80 percent for at least 36 months. Unfortunately, this is only data on one patient, but 36 months of improved motor skills at 80% is impressive! This is definitely information that leaves me wanting to know more and wondering if other diseases such as stroke can also be turned around. I tried searching for information on any possible negative side-effects of intranasal stem cell therapy, but it appears that the authors did not report on any. If anyone else can find any, please share, otherwise we can just hope that future research will soon determine what they are, if any!
This maybe absolutely new treatment for Parkinson Disease without invading brain cells such as having brain stimulus surgery. Their numbers are very significant compared with Parkinson disease medicines, which affect very slow to the disease while Parkinson disease develops faster.
ReplyDeleteThank you for posting this.
P.S. I wanted to see how the mechanism of intranasal treatment works, but couldn't access to whole article.
This maybe absolutely new treatment for Parkinson Disease without invading brain cells such as having brain stimulus surgery. Their numbers are very significant compared with Parkinson disease medicines, which affect very slow to the disease while Parkinson disease develops faster.
ReplyDeleteThank you for posting this.
P.S. I wanted to see how the mechanism of intranasal treatment works, but couldn't access to whole article.
This comment has been removed by the author.
ReplyDeleteThis is the first time I came across such a research, great job. I'm sure this will be very helpful in curing the disease. Stem Cell Treatment for Parkinson's
ReplyDelete