p38 & arthritis inflammation- p495k Hwisun Lee

Hi, I am hwisun Lee PSIO 495k discussion class. When we discussed The article that was concerned about CNS controlling arthritic join inflammation... But it did not mention about how important p38 signal is affecting the inflammation. So people do not really have any idea of how p38 works in actual system. So here is my suggestion for you to look at it. This is the general signal cascade in our system. http://www.sabiosciences.com/pathway.php?sn=P38_Signaling Please look at P38-alpha, Beta, gamma and Delta right before it signals to nucleic level where Gene expression occurs. It does make some sense why they want to control the level of p38 signal for treatment of inflammation. Thanks. P.S p38 does not only affect by inflammation but other stresses such as diabetes, etc.